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Posted by R4MSU on April 01, 2000 at 22:48:07:

CELEBREX IS A SULFONAMIDE DRUG. VIOXX IS NOT. PATIENTS WITH SULFONAMIDE DRUG ALLERGIES CAN NOT TAKE CELEBREX. ALLERGIC REACTIONS TO SULFONOMIDE DRUGS CAN INCLUDE HIVES, CONSTRICTION OF AIRWAYS, AND DEATH.
CELEBREX APPLIED TO THE FOOD AND DRUG ADMINISTRATION FOR AN ACUTE PAIN TREATMENT INDICATION AND WAS TURNED DOWN. VIOXX IS INDICATED TO TREAT ACUTE PAIN IN ADULTS, PRIMARY DYSMENORRHEA (MENSTRUAL PAIN), AND OSTEOARTHRITIS PAIN WITH ONCE DAILY DOSING.
CELEBREX HAS AN 11-HOUR DRUG HALF LIFE WHICH MEANS IN MOST PATIENTS THAT TWICE DAILY DOSING IS NECESSARY TO OBTAIN 24 HOUR PAIN RELIEF. VIOXX HAS A 17 HOUR DRUG HALF LIFE WHICH MEANS IT IS DOSED ONLY ONCE PER DAY AT HALF THE COST OF CELEBREX DOSED B.I.D. OR TWICE DAILY AND VIOXX PROVIDES 24 HOUR PAIN RELIEF.
CELEBREX IS METABOLIZED PRIMARILY VIA THE CYTOCHROME P450 SYSTEM AND VIOXX IS NOT. DRUGS THAT ARE PRIMARILY METABOLIZED VIA THE CYTOCHROME P450 SYSTEM USUALLY ARE MORE LIKELY TO CAUSE DRUG/DRUG INTERACTIONS IN PATIENTS TAKING MULTIPLE MEDICATIONS.
IN DENTAL EXTRACTION PAIN STUDIES CONDUCTED IN GREAT BRITAIN, CELEBREX HAD A 60 MINUTE ONSET OF ACTION VS A 30 MINUTE ONSET OF ACTION WITH VIOXX.
CELEBREX IS DOSED WITH 100MG OR 200MG CAPSULES.
VIOXX IS DOSED IN EITHER 12.5 MG OR 25 MG TABLETS FOR OSTEOARTHRITIS, AND A 50MG TABLET FOR ACUTE PAIN IN ADULTS OR PRIMARY DYSMENNORRHEA. VIOXX ALSO IS AVAILABLE IN A STRAWBERRY-FLAVORED 12.5 MG/5mL AND 25 MG/5mL ORAL SUSPENSION.
VIOXX IS EQUAL IN STRENGTH TO 2400 MG OF IBUPROFEN OR 150 MG OF DICLOFENAC.
BOTH DRUGS DECREASE THE EFFICACY OF ACE INHIBITORS WHEN TAKEN CONCURRENTLY. THE AVERAGE DECREASE OF EFFICACY IN CONTROLLING BLOOD PRESSURE TRANSLATES INTO 1 TO 3 LESS POINTS OR mmHG OF B.P. REDUCTION.
BEFORE DOSING EITHER DRUG, CONSULT WITH YOUR PHYSICIAN.
NEITHER DRUG HAS BEEN EVALUATED IN PATIENTS BELOW 18 YEARS OF AGE FOR SAFETY AND EFFECTIVENESS.
CELEBREX AND VIOXX ARE BOTH NONNARCOTIC.

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