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Posted by R4MSU on April 06, 2000 at 23:42:35:

In Reply to: Re: CELEBREX VS VIOXX:HOW THESE NEW ARTHRITIS MEDS DIFFER. posted by Carol on April 05, 2000 at 18:26:28:

: Do you know which drug family Vioxx falls under? : CELEBREX IS A SULFONAMIDE DRUG.

YES. VIOXX (ROFECOXIB), MECHANISM OF ACTION IS BELIEVED TO BE DUE TO INHIBITION OF PROSTAGLANDIN SYNTHESIS, VIA INHIBITION OF CYCLOOXYGENASE-2,(OTHERWISE KNOWN AS A COX-2 INHIBITOR). THE FDA CURRENTLY CLASSIFIES COX-2 INHIBITORS AS NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS). COX-2 INHIBITORS TYPICALLY ARE BETTER TOLERATED AND LESS LIKELY TO CAUSE GASTROINTESTINAL (GI) EVENTS (I.E. ULCERS) AS MOST FIRST GENERATION NSAIDS EVENTUALLY DO WITH CHRONIC ADMINISTRATION(I.E. IBUPROFEN).
COX-2 INHIBITORS ARE NOT A SUBSTITUTE FOR ASPIRIN FOR CARDIOVASCULAR PROPHYLAXIS BECAUSE THEY DO NOT AFFECT PLATELET FUNCTION.
VIOXX DOES TAKE APPROXIMATELY FIVE DAYS TO REACH A STEADY THERAPEUTIC STATE IN THE HUMAN BODY. IN ORDER TO OBTAIN MAXIMUM PAIN RELIEF AT THE BEGINNING OR ONSET OF THERAPY FOR ARTHRITIS PAIN, A 50 MG LOADING DOSE (TAKING 50MG AT ONE TIME THE FIRST DAY OF THERAPY) AND THEN BACKING DOWN THE DOSE THE SECOND DAY TO 12.5 MG OR 25 MG, MAY YIELD MORE IMMEDIATE PAIN RELIEF AND PAIN CONTROL. ALWAYS CONSULT WITH YOUR PHYSICIAN RE: POTENTIAL RISKS AND BENEFITS BEFORE ADJUSTING YOUR RECOMMENDED DAILY DOSAGE.
VIOXX IS NOT RECOMMENDED IN PATIENTS WITH MODERATE OR SEVERE HEPATIC (LIVER) INSUFFICIENCY OR IN PATIENTS WITH ADVANCED KIDNEY DISEASE.
VIOXX CAN BE DOSED ANYTIME, DAY OR NIGHT, WITH OR WITHOUT FOOD.VIOXX HAS ONCE DAILY POWER FOR ALL INDICATIONS : ACUTE PAIN IN ADULTS OR PRIMARY DYSMENNORRHEA (DOSED 50 MG ONE TIME DAILY), AND FOR OSTEOARTHRITIS PAIN:(DOSED 12.5 OR 25 MG ONE TIME DAILY).
VIOXX IS CURRENTLY BEING EVALUATED IN CLINICAL STUDIES FOR THE TREATMENT OF RHEUMATOID ARTHRITIS, INHIBITING THE PROGRESSION OF ALZHEIMER'S DISEASE, AND CAUSING REGRESSION OF POLYPS IN THE COLON (WHICH SOME RESEARCHERS THEORIZE MAY DECREASE INCIDENCES OF COLON-RECTAL CANCER).
SOME RHEUMATOLOGISTS ARE CURRENTLY PRESCRIBING 25 MG OF VIOXX ONCE DAILY FOR RHEUMATOID ARTHRITIS, ALTHOUGH THE FDA HAS NOT YET APPROVED VIOXX FOR TREATMENT FOR RHEUMATOID ARTHRITIS AT THIS DATE (4-6-00), PENDING COMPLETION AND REVIEW OF PHASE THREE CLINICAL STUDIES TO BE SUBMITTED BY THE MANUFACTURER (MERCK). DOSING VIOXX FOR RHEUMATOID ARTHRITIS PRIOR TO FDA APPROVAL IS CONSIDERED "OFF LABEL USAGE", DESPITE THE CLAIMS OF PAIN RELIEF MANY RHEUMATOID PATIENTS REPORT THEY OBTAIN FROM VIOXX.


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