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Posted by his dad on October 18, 2000 at 06:08:14:

In Reply to: Pepcid AC posted by Leigh on October 17, 2000 at 14:06:52:

We haven't tried pepcid, but we have seen great results with Prilosec. I have also heard anecdotal results with Zantac and Prevacid.
They all go after the excessive acid problem. Prior to doing that though, we had a diagnostic endoscopy (and a colonoscopy) done to check on the GI
tract and found esophagitis. Check out the journal article cited below. No pollips in the colon thank god (colonoscopy).
Prilosec is a prescription, and expensive, so unless your dr will give you some to try, you may need to go that route. Check this out if your child has diarhea,
weired bowel moevements or eating disorders. We also do gluten/casein free.

J Pediatr 1999 Nov;135(5):559-63
Related Articles, Books, LinkOut


Gastrointestinal abnormalities in children with autistic disorder.

Horvath K, Papadimitriou JC, Rabsztyn A, Drachenberg C, Tildon JT

Department of Pediatrics, University of Maryland School of Medicine, Baltimore, USA.

OBJECTIVES: Our aim was to evaluate the structure and function of the upper gastrointestinal tract in a group of patients with
autism who had gastrointestinal symptoms. STUDY DESIGN: Thirty-six children (age: 5.7 +/- 2 years, mean +/- SD) with autistic
disorder underwent upper gastrointestinal endoscopy with biopsies, intestinal and pancreatic enzyme analyses, and bacterial and
fungal cultures. The most frequent gastrointestinal complaints were chronic diarrhea, gaseousness, and abdominal discomfort and
distension. RESULTS: Histologic examination in these 36 children revealed grade I or II reflux esophagitis in 25 (69.4%), chronic
gastritis in 15, and chronic duodenitis in 24. The number of Paneth's cells in the duodenal crypts was significantly elevated in autistic
children compared with non-autistic control subjects. Low intestinal carbohydrate digestive enzyme activity was reported in 21
children (58.3%), although there was no abnormality found in pancreatic function. Seventy-five percent of the autistic children
(27/36) had an increased pancreatico-biliary fluid output after intravenous secretin administration. Nineteen of the 21 patients with
diarrhea had significantly higher fluid output than those without diarrhea. CONCLUSIONS: Unrecognized gastrointestinal disorders,
especially reflux esophagitis and disaccharide malabsorption, may contribute to the behavioral problems of the non-verbal autistic
patients. The observed increase in pancreatico-biliary secretion after secretin infusion suggests an upregulation of secretin receptors
in the pancreas and liver. Further studies are required to determine the possible association between the brain and gastrointestinal
dysfunctions in children with autistic disorder.

Comments:
Comment in: J Pediatr 1999 Nov;135(5):533-5


: I've heard about using Pepcid AC with autistic children. How does this work, has anyone tried it, and have they seen good results?



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