It appears you have not yet Signed Up with our community. To Sign Up for free, please click here....



Message Board
THIS MESSAGE BOARD IS NO LONGER ACTIVE. TO SEE OUR ACTIVE MESSAGE BOARDS, PLEASE GO HERE





Message
Posted by Nancy on September 04, 2000 at 23:35:25:

In Reply to: From http://ww.bhare.org/ Research into autism... posted by Margaret on September 02, 2000 at 18:25:53:

Look into Lyme Disease also

: Dr. Vijendra Singh

: Dr. Vijendra Singh, a neuroimmunologist, is working on the developmental aspect of the immune
: system and nervous system and itís relationships to autism. He firmly believes that up to 80% (and
: possibly all) cases of autism are caused by an abnormal immune reaction, commonly known as
: autoimmunity. Specifically, he is exploring the role of autoimmune factors (for example, viruses,
: autoantibodies, T cells, cytokines, ect.) because they serve as the prime targets of therapy with
: immune modulating drugs, he said.

: Dr. Singh thinks that autism is a complex disorder of a very complicated interaction between the
: nervous system and the immune system. He postulated a "Neuroautoimmunity Model of Autism"
: which he recently discussed at two recent meetings: First, the Biomedical Treatments for Autism
: and PDD Conference held in Orlando, Florida (May, 1999); and secondly, the Neuro-Immune
: Dysfunction Syndromes (NIDS) Conference held in Bethesda, Maryland (June, 1999). Briefly, he
: hypothesized that an autoimmune reaction to brain structures, in particular myelin sheath, plays a
: critical role in causing neurological impairments of patients with autism. He thinks that an immune
: damage to developing myelin (after a natural infection or vaccination) causes "nicks" or small
: changes in the myelin sheath, which ultimately leads to life-long problems of higher mental functions
: such as the skills for learning, memory, communication, social interaction, etc.

: Dr. Singh believes that autoimmunity has a strong prospect for treating patients with autism. He
: said that the lessons learned from other autoimmune diseases should also apply to autism. Because
: of autoimmunity involvement, he emphasizes the need to focus on immune therapies and urge
: doctors to pay attention to this line of research. Consequently, he says, there is a strong potential
: for restoring brain functions in autistic patients, including children as well as adults. With this goal in
: mind, Dr. Singh is committed to finding a cause and cure for autism.

: For further information, please contact him directly:
: Dr. Vijendra Singh, Ph.D.
: Biotechnology Center
: Department of Biology
: Utah State University
: 4700 Old Main Hill
: Logan, UT 84322-4700
: E-mail: singhvk@biology.usu.edu

:
: Sydney M. Finegold, M.D.

: The following hypothesis, based on the work of Ellen Bolte, is at the heart of the research that is
: being done at the Wadsworth Anaerobic Bacteriology Laboratory, West Los Angeles, CA.
: Hypothesis: A bacterial toxin, genetically related to the clostridial neurotoxins, causes the
: behavioral abnormalities associated with autism (via severe disruption of neurotransmitter release)
: in a narrowly defined subset of children.

: Many autistic children have severe gastrointestinal problems. Chronic diarrhea or loose stools is
: commonly reported from parents of autistic children. The research team at the Wadsworth
: Laboratory speculate that broad-spectrum antibiotics (frequently used to treat ear infections) may
: cause significant disruption of the protective intestinal tract flora and that this disruption may allow
: for colonization by one or more neurotoxin-producing bacteria. The neurotoxin produced in the
: intestinal tract then ascends to the central nervous system and creates an on-going state of
: neurotransmitter disruption.

: In an initial study, eleven children were treated with a minimally absorbed oral antibiotic. Nine of
: the eleven children showed improvement during therapy. One child had no change and the other
: possibly became worse. Pre-treatment stools were found to have numerous unidentifiable
: Clostridium species. No Clostridium were found in the stools from the "on-therapy" specimens of
: the children that benefitted from the treatment. Interestingly, the "on-therapy" stool specimen from
: the child who appeared to deteriorate during treatment contained multiple Clostridium species.
: The improvements in these children was short term and did not continue after treatment was
: terminated. However, the fact that there was improvement in such a short time period, shows that
: it is highly probable that a bacterial infection causes or worsens at least some (if not all) of the
: autistic symptoms in these children.

: The research team is working to identify the specific offending organism(s) involved, which causes
: the autistic symptoms. Upon isolation of the organism(s), the team will then be able to determine
: an effective treatment for the elimination of this "bug" from the gut. This work looks extremely
: promising. The BHARE Foundation feels it is simply a matter of time before this research yields
: discoveries that will directly benefit our children.

: Sydney M. Finegold, M.D.
: Professor of Medicine, Professor of Microbiology & Immunology
: Infectious Diseases Section
: VA Medical Center West Los Angeles
: UCLA School of Medicine

:
: Andrew Wakefield, FRCS

: Andrew Wakefield, leads a team of eight medical and scientific researchers, investigating a
: meta-hypothesis; that a complex relationship between a genetic predisposition, and early
: environmental exposures results in immune derangement and metabolic dysfunction. This primary
: sequence of events takes place in the gut which then triggers an autistic disorder.

: Andrew Wakefield's particular interest is in children who develop normally and then manifest an
: autistic disorder combined with gastrointestinal symptoms. A few years ago such cases were very
: rare. More recently there is evidence of a significant increase in their prevalence. Wakefield and
: colleagues have dubbed this syndrome 'autistic enterocolitis'. Examples of three current
: programmes receiving assistance from the BHARE Foundation are mentioned below.

: Histopathologist Dr Andrew Anthony, is investigating the gut pathology of autistic enterocolitis,
: and assessing possible non-invasive tests of specific features of the gut disorder seen in autistic
: enterocolitis. At present most children referred to Andrew Wakefield's colleagues require
: ileo-colonoscopy, an invasive procedure for which there is a lengthy wait. Children with autistic
: enterocolitis display a remarkable uniformity in their endoscopic and histological symptoms. At
: present 98% of affected children show a distinctive pattern of swollen lymph glands at the end of
: the small bowel and 88% have inflammation of the large bowel.

: Immunologist Dr Paul Ashwood, is investigating specific immunologic features of autistic
: enterocolitis. These concern the apparent dysregulation of certain helper T cells, thus impairing
: their ability to stimulate a full cytotoxic response from particular classes of cytolytic T cells.
: Epidemiologist Dr Scott Montgomery, is engaged in population-based studies to confirm the
: reported temporal trends in the epidemiology of autism. These studies will be used to explore
: explanations for the apparent increase in the incidence of autistic spectrum disorders and the
: reported changes in phenotype, such as an increase in the number of children with regressive
: autism. The work will include an investigation of the role of potential risk factors for autism,
: specifically the combination of environmental exposures resulting in disease among susceptible
: individuals. Identification of markers of susceptibility in both parents and the children themselves
: will also assist in defining the 'at-risk' group for specific exposures. Other current and planned
: investigations, include studies in virology, molecular biology, genetics and two trials of potential
: therapies.

: For further information please contact Andrew Wakefield directly, at the address below or by
: e-mail via robertsawyer@aol.com (Robert Sawyer handles all general enquiries and research
: funding for Andrew Wakefield and his research team).

: Andrew Wakefield, FRCS
: Reader in the Department of Histopathology and Medicine
: Reader in Experimental Gastroenterology
: Director, Inflammatory Bowel Disease Study Group
: Royal Free and University College Medical School
: Rowland Hill Street, London NW3 2PF

: Margaret.


Follow Ups

All times are GMT -7. The time now is 05:47 PM.



Site owned and operated by HealthBoards.comô
Terms of Use © 1998-2014 HealthBoards.comô All rights reserved.
Do not copy or redistribute in any form!