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Posted by Jaqui (UK) on September 18, 2000 at 18:41:43:

In Reply to: Secretin and urochholine, what are the ......... posted by Margaret on September 18, 2000 at 18:07:00:

There has been no research done on the long-term effects of secretin (prior to Victoria Beck's discovery it was only used as a once only administration treatment for diagnostic endoscopies). If it is assumed that it will react in long-term use similarly to other hormone replacement therapies such as insulin then the potential risks are a reduction in the bodies own ability to produce the hormone independently & antibodies to the pig secretin developing.
In the short-term hyperactivity and worsening of behaviour have been documented (this tends to be after the initial dose or when too high a dose is administered) this is temporary and most return to normal or improve subsequently. Seizure activity immediately after the IV administration has also been documented and this is not only a risk after the first infusion - thankfully this is rare.

Bethanecol (the proprietary neme for urocholine) has been used for years and there are very few reported side effects even with long-term administration. Unfortunately the vast majority of long-term users are adult males and no research or data is currently available on its long-term use in children. Short-term side effects are also very rare but these include nausea and vomiting, if not taken on an empty stomach; sweating; blurred vision and intestinal colic.



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