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Old 08-09-2005, 10:49 PM   #2
TNjewels TNjewels is offline
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Re: Can you help with these ANA test results?

It sounds like the ANA test you had done was a ANA-D or ANA Direct. Here's what I found out about the test ...

ANA Direct (ANA-D) is a new test that LabCorp has developed. Instead of the old methods of diluting the blood till they can no longer see the antibodies (1:80, 1:160, etc) this new tests allows them to "count" the antibodies in the blood sample. Normal ranges are 0-120. I contacted The American Society for Laboratory Science and asked for their assistance because I had this test and the results but my doctor could not tell me anything other than they were high. I wanted to know how to compare to the old ANA tests and what did my result of 1,075 indicate. I'll post their reply to me below.

Here is the reply I received from ASLS:

Dear Julie,

Thank you for contacting the American Society for Clinical Laboratory Science consumer web site with your question concerning your ANA test results. Your ANA test result is very high; your results are in U/mL units while some ANA test results are expressed as titers. Like many laboratory tests, different methods have different normal or expected ranges and the test result units may vary with the method. Your physician will look at your ANA test result relative to the expected range for the test method you had done to interpret your results. High ANA titers (>1:160) or high ANA test results in other units like U/mL are, in general, significant disease indicators. While ANA tests are diagnostically important, test results must be always be interpreted in the context of the clinical symptoms and presentation of the patient.

To compare ANA test results provided in different units (titers vs. U/mL e.g.), the results are looked at for clinical significance in the context of the patient's history, etc. High results by one test method should be high by another test method; low test results the same thing.
________

This info is from LabCorp's web site regarding their test:
LabCorp converted to atechnology for antinuclear antibody (ANA) testing that providesmore objective, higher quality results than traditional methodolo-gies. The new technology provides a direct measurement of autoan-tibodies relevant to ANA testing from a single patient sample. Thepresence of characterized autoantibodies in conjunction with a pos-itive ANA result and symptomatology can have far greater clinicalsignificance than an uncharacterized ANA result alone, thereby pos-itively affecting patient care.

Hope this all helps you have more understanding regarding the ANA Direct blood tests.

Julie