I used retina micro and benzoyl peroxide. This combination was the best for me out of all the topical treatments I've tried. I found that the retina dried my skin too much and made it peel and look awful if I slept with it on at night. So for years I put benzoyl peroxide on when I slept and retina micro on during the day under my make up (as was suggested by my derm). This worked pretty well, alhough neither really cleared my skin completely. I'd still wake up with a large zit every so often. Thankfully accutane has cleared me up more after a month, than retina and benzoyl have done for years!