Sach34, I had irritable bladder problems for 10 years. Like yours, my urologist suspected interstitital cystitis but decided to hold off on the test because I had so many other things going on (severe hedaches, joint pain, low-grade fever, anemia, etc.) It's hard to believe, but my urinary problems disappeared a few months into Plaquenil. (Amazingly, so did my severe irritable bowel problem). Plaquenil & sun avoidance have helped tremendously (although I hate the no-sun part
). I hope you can give it another try. Best wishes! from Vee