I was on LDN for a number of months and I had immediate drop in pain. Unfortunately about 4 months in, I developed nausea and vomiting and was unable to tolerate any longer, but I cannot say enough good things about it. I was more mentally alert, went almost 3 months without having to take any pain meds other than a couple of incidents. I was moving better, felt great. I really was hoping it was my magic cure. Please don't take my failure to tolerate as a reason not to try as I have had long-time issues with medication allergies and wild side effects. I am not your "normal" test subject. I would still be taking it if I was able to tolerate it. I did write a thread here on my experiences, both here and on the Lupus board. Hope you have good results as well.