I was told to take at night. I did some research and it seems the body replenishes the body's natural endorphins between 12 and 3AM, so you take this to boost the body's natural response. I suppose if one worked a different shift or slept during a different time, you could adjust. I did not mention earlier, but I did want to add that I slept much better and stayed asleep all night long while on this med. This was a welcome response for a chronic insomniac that had tried all the sleep meds with no real relief. I now am back to my 1-3 hours of sleep and it is the pits. Just for your info.