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Old 09-06-2010, 05:25 AM   #7
Baptista Baptista is offline
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Re: PSA Relapse Following Salvage Radiotherapy, can you help?

Jim,
GuamJohn,
JohnT

Thank you for the comments on my post. I am relying very much on your insights and material from the net. < edited > has not sent me yet a copy of Myers’ BIBLE so I have many question marks to clarify. Could you please give me an insight on the following, if possible?

Am I wrong in thinking that practitioners of HT follow protocols, and that such is set at the beginning of the treatment? Or is HT fixed on the basis of “trial & error” along the period of treatment?

What kind of Monitoring is used by practitioners to certify If a cancer (biology) is responding to “protocol A”? And how long does it take to change protocols (A to B)?

I understand that HT is applied on a Single, Dual and Triple drugs each directed to different purposes. The classical ADT3 seems to be a combination of an Anti-androgen + a LHRH agonist + a 5α blocker. Why is a LHRH agonist used on single protocols if it is known that it causes “flare”?
Being from the same group, is there a drug that can be considered better than the other?

Very little is written about cases using estrogens (DES) and orchiectomy surgery. It may be because most materials on the net are posted in the United States where those treatments are less common. Do you know of protocols incorporating these kinds of treatments? Are they included in the same scenario as on a Single, Dual and Triple Blockage?

I believe that the behavior of cancer cells is influenced on the principle of adaptation to newer situations. They have the power of changing their way on how to survive, once supplies of testosterone are cutoff. Albeit the release from the side effects, to trick the cells into believing that “testosterone is going to be there always” may be the positive approach of the intermittent application (now you have it, now you don’t). Have you came a cross of any report on this basis? If such, orchiectomy should not qualify for an intermittent methodology? What about estrogens, are they proper for an intermittent approach?

Androgen deprivation by surgery or medication gives differ results in terms of Erection Dysfunction. In surgery ED is permanent. Is there any other aspect or side effect one should consider as important when deciding between both treatments?

My doctor is a urologist and belongs to a team of surgical oncologists experienced in the diagnose, and treatment of cancer. They practice in Lisbon biggest hospital. I think that I am in good hands. However, if unsatisfied I would not mind in changing “clubs”. Do you think that it would be possible to have a treatment applied on the “other side of the globe” far from where you live? And could the monitoring job be done by a third party?

I read that HT drugs ‘side effects are nasty. Most of them require medication to counter the symptoms and many of the drugs require previous health fitness, as a condition for its application. In this regard, what kind of questionnaire was given to you at the beginning of your treatment? And in your experience what could you suggest to patients on HT, apart from what it is written on the BIBLES (Myers and Scholz)?

Thank you in advance for the help and interest in my case.

Best Regards,
Baptista

Last edited by hb-mod; 09-11-2010 at 12:18 PM. Reason: Please don't post unapproved websites, per Posting Policy. Thanks!