Hi there, I can honestly say, its been about a month now since I had my injection, I notice a little difference when I walk downhill, so thats good. It has helped in that respect, but as far as the toothache that I have in my knees and lower legs, it just hasnt helped. Give it a little more time. These things can take a good month to fully kick in. If your still in bad pain after that, I'd say your going to have to do a TKR. I live with constant aching and discomfort. Its incredibly annoying, but I dont think I have the kind of pain you do. Please let me know how your doing.