Re: Is it reasonable to take 80mg of Prilosec to equal 40mg Nexium?
Most studies show that 40 mg of Prilosec is the same as 40 mg of Nexium, but there's always individual variation in response.
When you should take it might depend on when your symptoms are the worst. If it mostly bothers you in the daytime, take it first thing in the morning. If it keeps you up at night, take it either before bed or before dinner.