I've been on PPI's of one form or another for over a decade. I've only gone off of them for short periods of time for testing when my reflux was extremely severe.
About 4 years ago, I had a successful Nissen Fundoplication. Except for a few months about a year after surgery, I don't experience any of my previous reflux symptoms at this point. I've stayed on my Dexilant 60mg daily since it came on market not long before that. I've been visiting regularly with THREE specialists and my PCP who all recommended I stay on it because prior to surgery my acid was literally life threatening because it was coming up in a gaseous form and irritating my lungs and causing severe breathing problems.
I'm very scared of the possibility of of any acid triggering my asthma again if I have problems coming off of the Dexilant. Once my breathing issues are triggered, my issues become severe. I visited with my PCP and he was very reluctant because he knows how severe my asthma was and how difficult it was to get under control. He agreed to let me try to wean to H2 blockers, one per day to start and 2 per day if I start with symptoms. He did give me the stipulation that if I have much trouble I will go back on the Dexilant.
The reason I'm taking this "leap" of faith now is that I'm dealing with TMJ issues and my orthodontist is very worried about my lack of calcium absorption due to the PPI's. Even the supplements I have taken aren't probably doing much good since the calcium really isn't absorbed well. My PCP agreed that this could be worthy of concern. That is the only reason he was willing to let me try this. He did to labs to check my Calcium, Magnesium and Iron so that we can monitor things.
Here's hoping for positive results.