Re: Can't get PSA to zero
Finasteride (Proscar) can reduce DHT by 70% and Dutasteride (Avodart) by 90% from baseline levels, so it's useful to determine what the baseline is before such therapy begins. Because testosterone is metabolized into the more potent androgen DHT, Testosterone levels will rise when that metabolic pathway is blocked. DHT is much (5-10x) more potent at stimulating PC, so that's OK. It's often used together with a GnRH agonist (e.g., Lupron) or antagonist (e.g., Firmagon), and an anti-androgen (e.g., Casodex, Zytiga or Xtandi).