Men don't learn from their own experience, you want to learn from your mom? LOL I give you a credit that you searching and asking, this is great. I am sure you will learn more as it goes. Just always keep in mind to be careful and check with your DR.
Yes, biologics are very harsh and bring immune system very low. I don't know what makes me sicker RA or biologics. ;-)
They prescribe (Rx) them to those who didn't benefit from more mild treatments (like MTX which is mild form of chemo therapy).
Have a nice vacation!