I have been rubbing MSM cream with Glucosamine into my knees at night for many months now. I diffentally think it works for me. For some reason, as soon as I shower it off, my knees start in aching more. I rub a good amount back into them, go to bed and they feel good in the AM. I make sure I don't run out of that. 4 oz. costs only $6.38. Not on sale, they say it costs $15.95, but I've never seen it 'off' sale. Good luck.