| Re: Question from a newbie. Please read!!!
The lump is a major symptom of laryngopharyngeal reflux (LPR), where the the upper esophageal spinchter is weak and the acid leaves the esophagous and goes into the throat. LPR usually must be treated with 2 PPIs per day.
Prilosec is the oldest PPI on the market. All the other PPIs are by prescription only. You need to try each PPI until you find the one that works for you best. There is no general concensus on this board for the best PPI - as everyone seems to respond uniquely. Nexium is probably the most different of the PPIs, and is also the latest to market. There is some thought that it may be better for LPR patients, but everyone is different.
The prescription PPIs that are available are Nexium, Prevacid, Aciphex and Protonix.
Motherisk, a Canadian organization in Toronto, has done studies on PPI use in pregnant and lactating females, and has found zero correlation between PPI use and increased defects in infants. There are no US-based studies that I am aware of.
I personally have used Nexium 2x a day for 3 years to control LPR and I am doing very well.
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