It appears you have not yet Signed Up with our community. To Sign Up for free, please click here....

Acid Reflux / GERD Message Board

Neuropathy as Alternative Cause of Chronic Cough - Neurontin Treatment

Post New Thread   Closed Thread
LinkBack Thread Tools Search this Thread
Old 08-26-2006, 11:41 AM   #1
Senior Veteran
Join Date: Sep 2005
Posts: 565
aswander HB Useraswander HB User
Neuropathy as Alternative Cause of Chronic Cough - Neurontin Treatment

Hi LPR Team,

I just got back from a visit with Dr Anthony Jahn, a well-known Dr in NYC who deals with a lot of LPR, especially in the singing community. I really hate changing doctors so frequently, but I've moved a lot and it seems that all the best tri-state LPR docs refuse to take my insurance, United Healthcare - otherwise I'd still be going to Sataloff and Lyons in Philly. Dr. Jahn was very nice, and proposed an alternate theory to LPR - he suggested that it was possible I had vagal neuropathy - which is basically a hypersensitive larynx. Though I am strongly inclined to disagree with him about neuropathy as a stand-alone theory (I have too many classic LPR symptoms that don't fit in with neuropathy), I am more open to the possibility that I have a hypersensitive larynx either as a result of the reflux or a hypersensitive larynx that makes the reflux experinece even worse. (Hypersensitive larynx does not explain the burning sensation in my nasal passages whenever I begin coughing/refluxing and the subsequent stuffed up sinusitis-like symptoms. Nor does hypersensitive larynx explain why I feel great when laying in bed, and only reflux during upright positions).

Anyway, there's a point to this. It seems that vagal neuropathy is treatable with neurontin to some degree. Yes, neurontin is a rather strong drug with many undesriable side effects, but for those of you who fail to respond to PPIs, this is just another angle to try.

I just googled Neurontin and LPR and discovered that Dr. Peak Woo, another well-known New York City ENT who specializes in laryngeal disorders, had done a study in 2003/2004 that he presented, along with Dr. Bryant Lee in 2004 at the 2004 American Laryngolgy Association Convention. He claims that 17 of the 23 subjects responded positively to neurontin treatment.

Here's the summary (I don't have the article in full):

Chronic Cough as a Sign of Vagal
Neuropathy: Diagnosis, Work Up and
Treatment Paradigm
Bryant Lee, MD*
Peak Woo, MD
New York, NY
Chronic cough is often attributed to reflux, post nasal drip or
asthma. We present 23 patients with chronic cough as a manifes-
tation of sensory neuropathy involving the superior or recurrent
laryngeal nerves.
Twenty-three patients have been identified with sudden onset
of cough with laryngospasm after viral illness or surgery. Cough
and laryngospasm were the most common complaints. Fifty-two
percent (12/23) had concomitant unilateral superior laryngeal
nerve (SLN) or recurrent laryngeal nerve (RLN) motor neuropa-
thy documented by EMG. After a negative workup or treatment
for reflux, asthma or post-nasal drip, these patients were treated
with Gabapentin (Neurontin) at 300 – 90 mg per day.
Symptomatic relief was achieved in 17 patients.
Sensory neuropathy of the RLN or SLN should be considered
in the work up and management of patients with cough and

In addition, Dr. Jahn also gave me the tname of a Canadian doctor who is doing research into using neurontin as a treatment for this condition - his name is Murray Morrison and he is a doctor at Vancouver General Hospital, Willow Pavillion, in Vancouver, British Columbia.

Nonetheless, I found it interesting that Dr. John would propose this alternative hypothesis, yet he suggested that I take the following steps before I experiment with Neurontin -
1. Have a 24 hour monitoring done to evaluate reflux breakthrough while on PPIs.
2. If breakthrough exists, strongly consider the Nissen Fundoplication (I asked him about the Stretta procedure but he wasn't familiar with it)
3. If my breakthrough symptoms do not go away and I choose not to do the Nissen, then consider Neurontin.
4. If I choose to do the Nissen and the symptoms still don't go away, consider trying Neurontin.

I also asked him about his experience with other LPR patients. He told me he's had about 100 or so LPR patients, and only 1 or 2 of them chose to ultimately do the Nissen, but it helped that individual (s).

Sponsors Lightbulb
Old 08-26-2006, 03:32 PM   #2
Senior Member
Join Date: May 2006
Posts: 178
tlily HB User
Re: Neuropathy as Alternative Cause of Chronic Cough - Neurontin Treatment


You are so knowledgeable around this subject. Thank you for keeping us all up to date. You are so helpful with all your infomation. Your other post listing all the well known Doctors is really good to know as it is very difficult to find a doctor that has much experience with LPR. Some do not even know what it is.

Again thanks for all your help.


Old 08-26-2006, 04:23 PM   #3
Senior Veteran
Join Date: Sep 2005
Posts: 565
aswander HB Useraswander HB User
Re: Neuropathy as Alternative Cause of Chronic Cough - Neurontin Treatment

Hey thanks for the compliment. [removed]Hopefully try to tie up some of the loose threads. The one thing that bugs me constantly is the lack of understanding of how the larynx is affected by acid and pepsin. What is taking so long? Why don't we understand the path of acid, and how acid can possibly jump all the way up to the larynx without causing erosions in the lower esophogous? These things keep me up at 3 AM sometimes.

To my detriment, a lot of male doctors have found me to be "overinformed" and "rehearsed". Funny that female doctors have never patronized me, but male doctors do time and time again just because I'm prepared and organized. But like many of you, having had LPR for so many years (4 in my case), I've had plenty of time to think about the symptoms and problems stemming from this condition.

And the only problem with seeing LPR doctors who specialize in singers, is that (with all due respect to the creative arts), artists can be a little flakier than corporate types, and perhaps not present themselves as effeciently and thorough as non-artists, so maybe these doctors are used to less buttoned-up patients than what they usually see.

Last edited by HBMod07; 08-27-2006 at 05:58 AM. Reason: Indicating any type of proffession in the Medical field is not permitted, future or past. Please review the posting Rules

Old 08-27-2006, 03:54 AM   #4
Senior Member
Join Date: May 2006
Posts: 178
tlily HB User
Re: Neuropathy as Alternative Cause of Chronic Cough - Neurontin Treatment


Seriously what makes me angry when doctors sometimes are too quick to say that everything is stress when they can not find out a reason for someting to be happening. Noe yes I know that stress and anxiety contributes to reflux, but do not blame it all on that and minimize someones symptoms.

Glad you going to pursue what you seem to be so good at. Would truely love to read your thesis some day. Mine was on anxiety and stress. YOu go girl.


Last edited by HBMod07; 08-27-2006 at 05:59 AM. Reason: Indicating any affiliation in the Medical field is not permitted. Please review the Posting Rules

Old 12-23-2006, 07:59 PM   #5
Junior Member
Join Date: Feb 2006
Location: Warren, OH
Posts: 11
SandySoo HB User
Re: Neuropathy as Alternative Cause of Chronic Cough - Neurontin Treatment

Aswander, did you try the Neurotin? Did it work?

Old 12-25-2006, 03:58 PM   #6
Senior Veteran
Join Date: Sep 2005
Posts: 565
aswander HB Useraswander HB User
Re: Neuropathy as Alternative Cause of Chronic Cough - Neurontin Treatment

No, I never tried Neurontin because it has a really high birth-defects rate and I'm trying. I'll try after I'm done with the child-bearing years if nothing else is available. There are a few people on the other board that use it.

Closed Thread

Similar Threads
Thread Thread Starter Board Replies Last Post
Small Fiber Neuropathy#2 will54 Neuropathy 110 05-10-2010 11:07 AM
Neurontin for neuropathy symptoms jwood Neuropathy 47 05-09-2010 01:01 PM
The Insidious progression of Peripheral Neuropathy paulo60 Neuropathy 3 01-21-2008 07:34 AM
Does this s/l Neuropathy & Chronic Fatigue ? (Long) Sandilyn Neuropathy 5 04-15-2007 04:05 PM
Neuropathy - FYI Pill regiment thylantyr Neuropathy 18 01-19-2007 05:15 AM
For Those Who Know About Diabetic Peripheral Neuropathy...I have a question... karihager1982 Neuropathy 4 08-28-2005 07:44 PM
help,looking for alternative med for fungal sinusitis ebrbetty Sinus Problems 22 05-12-2004 05:57 PM
Does Neuropathy cause chronic fatigue? builder Neuropathy 7 01-03-2004 02:31 AM

Thread Tools Search this Thread
Search this Thread:

Advanced Search

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is Off
HTML code is Off
Trackbacks are Off
Pingbacks are Off
Refbacks are Off

Sign Up Today!

Ask our community of thousands of members your health questions, and learn from others experiences. Join the conversation!

I want my free account

All times are GMT -7. The time now is 04:32 PM.

Site owned and operated by™
Terms of Use © 1998-2016™ All rights reserved.
Do not copy or redistribute in any form!