i just read also on internet that the time use for antacids and ppi's was 4-8 weeks and there is a reason. it said, "long term use can cause body to produce an extra amount of the hormone called gastrin. gastrin is the substance that tells your stomach to make more acid. there are gastrin receptors on the esphogeal, pancreatic, and gastric cancer cells, and over-production of gastin can casue these cancer cells to grow too large, thus greatly increasing the risk of getting cancer in these areas. so in another words, if you take ppi's for longer than 8 weeks it can cause your stomach to make more acid. just what we need