Actually, I have always taken my accutane at night before I go to bed. My doctor said this was okay because I had eaten an evening meal and snack
before to avoid the stomach upset.
Then I take the spiro at aroung 1:00 in the afternoon. This way it's well after the accutane and yet it's well before bed and that means less up and down during the night.!! I also take the yasmin at night with the accutane. I only usually take the accutane on mondays, wed. and fridays.......
Anyway, it has never bothered me and the derm said it was a fine schedule.