I looked up some info about this subject. This is the only case where I found any mention of depression. Also, keep in mind that spiro is a diuretic, which means that if you are not drinking enough water while taking it, you could simply be dehydrated and feeling weak or tired because of that, which might look like depression, but isn't. See below under "comments".
Brand Name Manufacturers
Aldactone by Searle
Spironolacton by ? in Bulgaria
Uractone by ? in Italy
Verospiron by ? in Hungary
Mostly inhibits production of testosterone at the stage of 17-hydroxylation, and competes with DHT (dihydrotestosterone) for bonding at peripheral receptors. It is also said to intensify catabolism of androgens, and activate conversion of testosterone into estrogens.
25, 50, 100mg oral tablets
Approved by U.S. FDA
Congestive heart failure. Elevated blood pressure. Fluid retention. Hyperaldasteronism. Inadequate pottasium retention. Liver cirrhosis.
Elevated potassium levels. Inadequate urine production. Kidney disfunction.
Confusion. Dizziness. Drowsiness. Headache. Lethargy. Loss of precise motor control.
Cramping. Diarrhea. Dry mouth. Gastric ulceration and other stomach inflammation. Vomiting.
Acne. Itchy, fluid-filled patches of skin. Increase of body and facial hair. Red skin patches from capillary congestion.
Deepening of the voice. Drug fever. Pottasium retention. Severe decrease of blood granulocytes. Sodium loss.
One person reported suicidal depression as an adverse effect. The brand-name formulation tastes awful; the generic formulation is much less offensive.