Side Effects: Frequency:
Chapped lips 90%
Dry skin and itching 80%
Dryness of nose, mild nosebleed 80%
Irritation of the eyelids and eyes 40% - Vitamin E 400 IU each day may lessen this side effect.
Joint and muscle pains 15%
Temporary hair thinning 10%
Intestinal symptoms 5%
Urinary symptoms 5%
Increased sensitivity to sunburn 5% - the use of daily sunscreen will help prevent this side effect.
Decreased night vision <1%
Depression, thoughts of suicide <1%
Isotretinoin may increase the level of blood fats, sometimes to risky levels. Occasionally it may affect the liver. That's why regular blood tests are necessary when you are taking isotretinoin; these tests must be done when you have fasted for 12 hours (no breakfast), so that the blood fat determinations are reliable. A baseline blood chemistry test is established before patients start isotretinoin.
Accutane can cause birth defects to unborn children if taken during pregnancy.
Serious side effects are minimal in patients who are properly monitored.
Hope this is what you wanted to know.