Re: Weakness in both legs even taking meds.
You may be experiencing cramps from calcium or magnesium imbalance (low levels) or anemia. Restless leg syndrome (Willis-Ekbom disease) occurs at night and involves pain, sometimes cramps, but not usually weakness. Pain and weakness could be from muscle inflammation, low potassium. I would see your Dr and ask for the following tests: Serum calcium, magnesium, potassium, ferritin (stored iron-for RLS), blood count, CK (muscle enzyme for inflammation), and BUN/creatinine (kidney problems can cause RLS). I know that is a bunch of stuff, and might be whittled down with a little more clarification on history and exam.