I've asked a few allergists and anesthesiologists (who often have to deal with it). Between them, they say they've seen 1 case with a total of about 250 years of active practice between them.
In most cases its an allergic reaction to the delivery mechinism rather than the drug, or to a preservative in the drug. Its pretty simple and safe for either an allergist or anestheisologist to do a simple skin ***** test to see what the real situation is.
By the way the reason that anethesoligists come up in this discussion is because this drug, or a variation of it, is used so much in surgury that they have learned to test for allergies.
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allergic reactions to Novocain 
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