You should only take echinacea when you first start feeling sick...you should not take it every day or it is not effective. If you take a LOT of echinacea AS SOON AS you start feeling the tiniest bit sick, it will often prevent you from getting more sick, IME.
Zinc, vitamin C, alpha-lipoic acid, vitamin E...all of these are very good for you and strengthen the immune system. Also, laughter, sex, and exercise are AMAZING immune system boosters!
Eating a healthy diet -- organic, lots of fresh vegetables and fruit, whole grains, avoiding processed and refined foods...will go a long way.
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