HI Shirley, good thread! The website I use for a great deal of my research for my studies also states on this subject that:
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"...Despite the slight variations in the mode of action of the 3 cholinesterase inhibitors, there is no evidence of any differences between them with respect to efficacy," presenter Jacqueline Birks, MA, MSc, CStat, from the Cochrane Dementia and Cognitive Improvement Group, University of Oxford, England, told Medscape..."
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And at the moment, there are no published long-term trials directly comparing all 3 Cholinesterase Inhibitors which are cholinergic drugs — donepezil, galantamine, and rivastigmine.
Further evidence and studies goes on to state that these same drugs are being trialled for MCI (Myocardial Infarct) patients and appears to be successful.
So, it looks like yes, there is a LITTLE improvement.
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"...Patients suffered more adverse effects, such as nausea, vomiting, and diarrhea on the drugs, than on the placebo, but these side effects are not so bad that they outweigh the benefits," Ms. Birks said. "From the evidence provided by one trial there appear to be fewer adverse events associated with donepezil compared with rivastigmine..."
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And the article goes on to state that there has been a noted improvement in Severe Dementia.
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