It appears you have not yet Signed Up with our community. To Sign Up for free, please click here....



Alzheimer's Disease & Dementia Message Board
Post New Thread   Closed Thread
LinkBack Thread Tools
Old 06-07-2012, 09:57 AM   #1
Senior Veteran
(female)
 
ninamarc's Avatar
 
Join Date: Mar 2011
Location: Canada/USA
Posts: 1,703
ninamarc HB Userninamarc HB Userninamarc HB Userninamarc HB Userninamarc HB Userninamarc HB Userninamarc HB Userninamarc HB Userninamarc HB Userninamarc HB Userninamarc HB User
Vaccine that improves the symptoms

I just came across this article today:

"Researchers in Sweden have developed a vaccine that helps improve the symptoms of people with mild to moderate Alzheimer's disease.

The study, published in Lancet Neurology, says this is a breakthrough in the search for a cure to the dementia disease.

The researchers noted the vaccine focuses on the amyloid precursor protein, which resides in the outer membrane of nerve cells and that, instead of being broken down, can form a harmful substance called beta-amyloid, which accumulates as plaques and kills brain cells.

In the second clinical trial in humans, the researchers found 80% of patients developed their own protective antibodies against beta-amyloid without suffering any side-effects over the three years of the study.

The researchers now want to use the vaccine, called CAD106, in a larger clinical trial to see if they get the same results."

This is not a cure but it is better than nothing.

Regards,
Nina

 
Old 06-07-2012, 09:42 PM   #2
Senior Veteran
(female)
 
Join Date: Jul 2007
Location: charlotte, nc, usa
Posts: 7,135
Gabriel HB UserGabriel HB UserGabriel HB UserGabriel HB UserGabriel HB UserGabriel HB UserGabriel HB UserGabriel HB UserGabriel HB UserGabriel HB UserGabriel HB User
Re: Vaccine that improves the symptoms

I saw the same information. The original trials were in mice. There was a side note that effectiveness in animal studies does not necessarily translate to effectiveness in human studies. The first human trials was only to determine if the CAD106 was safe for humans. Can a human tolerate the treatment well. It is only with the further trials that they determine if the treatment is effective in the treatment of Alzheimer's. This may or may not be the case. Many have gotten this far and failed. So I am waiting for definitive information that it is effective in more than mice

Love, deb

 
Sponsors Lightbulb
   
Old 06-08-2012, 04:27 AM   #3
Facilitator
(female)
 
Join Date: Apr 2005
Location: Birmingham, AL
Posts: 14,859
Titchou HB UserTitchou HB UserTitchou HB UserTitchou HB UserTitchou HB UserTitchou HB UserTitchou HB UserTitchou HB UserTitchou HB UserTitchou HB UserTitchou HB User
Re: Vaccine that improves the symptoms

The Lancet is one of the best known and most highly respected medical journals in the world. Getting published there is very difficult. Hopefully this research will move treatments forward.

 
The Following User Says Thank You to Titchou For This Useful Post:
ninamarc (06-08-2012)
Old 06-08-2012, 09:37 AM   #4
Senior Member
(male)
 
Join Date: Apr 2012
Location: New York
Posts: 269
Luau HB UserLuau HB UserLuau HB UserLuau HB UserLuau HB UserLuau HB UserLuau HB User
Re: Vaccine that improves the symptoms

Seeing results in mouse models is very encouraging. However, as Deb says, having it work in mice does not guarantee that it will work as well in human. First will be a Phase I clinical trial, a limited sampling size with primary goal to assess if the treatment is safe for humans, and secondarily to determine efficacy of the treatment. If it passes Phase I, then it will move forward into Phase II, which is a much larger sampling size to assess side effects, outcome, etc. Then Phase III, etc etc. It is a long road for drug development, and more treatments than not do not make the full journey from Phase I to FDA approval.

 
Old 06-09-2012, 08:28 AM   #5
Senior Veteran
(female)
 
ninamarc's Avatar
 
Join Date: Mar 2011
Location: Canada/USA
Posts: 1,703
ninamarc HB Userninamarc HB Userninamarc HB Userninamarc HB Userninamarc HB Userninamarc HB Userninamarc HB Userninamarc HB Userninamarc HB Userninamarc HB Userninamarc HB User
Re: Vaccine that improves the symptoms

That is true it will take a while. At least we get to know where they stand for.

Nina

 
Old 06-10-2012, 03:05 PM   #6
Newbie
(male)
 
Join Date: Jun 2012
Location: Sevierville,Tn. USA
Posts: 2
JLNREB HB User
Re: Vaccine that improves the symptoms

Quote:
Originally Posted by ninamarc View Post
I just came across this article today:

"Researchers in Sweden have developed a vaccine that helps improve the symptoms of people with mild to moderate Alzheimer's disease.

The study, published in Lancet Neurology, says this is a breakthrough in the search for a cure to the dementia disease.

The researchers noted the vaccine focuses on the amyloid precursor protein, which resides in the outer membrane of nerve cells and that, instead of being broken down, can form a harmful substance called beta-amyloid, which accumulates as plaques and kills brain cells.

In the second clinical trial in humans, the researchers found 80% of patients developed their own protective antibodies against beta-amyloid without suffering any side-effects over the three years of the study.

The researchers now want to use the vaccine, called CAD106, in a larger clinical trial to see if they get the same results."

This is not a cure but it is better than nothing.

Regards,
Nina
is there any hope this "clinical trial" can be over here (the us)?time is loss!!

 
Closed Thread




Thread Tools

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is Off
HTML code is Off
Trackbacks are Off
Pingbacks are Off
Refbacks are Off




Join Our Newsletter

Stay healthy through tips curated by our health experts.

Whoops,

There was a problem adding your email Try again

Thank You

Your email has been added




Top 10 Drugs Discussed on this Board.
(Go to DrugTalk.com for complete list)
Aricept
Aspirin
Ativan
Morphine
Namenda
  Reminyl
Risperdal Seroquel
Xanax
Zoloft




TOP THANKED CONTRIBUTORS



Gabriel (757), ninamarc (157), Martha H (124), meg1230 (93), angel_bear (68), jagsmu (55), Beginning (51), TC08 (44), ibake&pray (43), debbie g (37)

Site Wide Totals

teteri66 (1164), MSJayhawk (999), Apollo123 (898), Titchou (833), janewhite1 (823), Gabriel (758), ladybud (747), sammy64 (667), midwest1 (665), BlueSkies14 (610)



All times are GMT -7. The time now is 05:01 AM.



Site owned and operated by HealthBoards.comô
Terms of Use © 1998-2014 HealthBoards.comô All rights reserved.
Do not copy or redistribute in any form!