Me: PCOS (polycystic ovarian syndrome- includes quite a few "symptoms", one being insulin resistance/metabolic syndrome), hypothyroidism, hypoglycemic, GAD (generalized anxiety disorder)
Side Effects: First few weeks, nausea and dry mouth. These tapered off (unless I forgot to take it for a couple of days, side effects would return). Long term side effects include decreased appetite (excellent! i liked this part!) but my serotonin levels increased so I craved sugars and carbs like mad! May not be a problem for those that don't have issues with diabetes/insulin response/current craving for sweets. Also had major insomnia. Helped anxiety a bit, but not worth staying on long-term.
I gained weight on this medication because my body was increasing its serotonin levels and decided it liked sugar and carbs way too much, and couldn't go without it. I take additional medication for my insulin resistance and hadn't had problems until taking Cymbalta, so watch out for that, as it was unexpected! I don't want to gain weight and keep eating sugar, so I am tapering off with 30 mg (took 60mg before).
May try Wellbutrin, suggested by my doctor, as she mentioned that it has recently been approved for help with anxiety as of this year, 2006. Cool! I hate taking medicine though and I am a recent vegan and proud owner of a treadmill, so I am going to try to do without.