Two years ago my sister was in a car accident. It caused her to have tissue damage so she was prescribed cortizone shots. She was given a very large amount in 3 injections, a few weeks apart. Within a month she was diagnosed was addisons, due to the fact her adrenal gland was detecting to much cortizone. She blew up like a blow fish, along with alot of mental stress. Its been a while now and her numbers are finally going back to normal, but she is on the verge of a break down. Along with this, the place on her lower spine where the injecting were given is now free of fat, muscle and almost skin, it will most likely need a skin gragh within 2 yrs. I guess its rare but cortizone can do this. If anyone has heard of this it would be nice to give my sister some reasurance she is not the only one.