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I've read about an experience someone on this board had with regards to Toprol (can't remember whether it was the extended release version or the normal version). I seem to recall that he/she said something about falling into a depression when he/she took it (not withdrawing). But since beta blockers are sometimes prescribed to handle anxiety, which *could* be related to depression, it would make sense if you were to go off it, some amount of depression would set in, although depression is defined and felt differently by different people!

If I find the post, I'll put the link here.

[Edit]

Found two posts:

http://www.healthboards.com/boards/showthread.php?t=154428&page=2&pp=5&highlight=toprol+depression

http://www.healthboards.com/boards/showthread.php?t=58554&highlight=toprol+depression

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Hi Crabby!
Depression is a HUGE side effect with beta blockers and I wish I could post the links for you where it is mentioned often. The pharmaceutical monographs I've read list it but not as one of the more common adverse reactions. They lie! :mad:

I was diagnosed with hypertension about a year ago (no other health issues) and a beta was the first drug prescribed.
I cannot tell you loudly enough what a sledge-hammering, abject depression I fell into! Unrelated to ANYTHING. My best friend, who is rather intolerant of my ocassional hypochondriacal issues (boy-who-cried-wolf syndrome!), was the first person who said: "Hey something is really wrong here since you started that med".

Needless to say, I'm off it now and happy on an angiotensin 2 receptor blocker (Diovan) with good blood pressure control and no side effects.:bouncing: (except I seem to have turned green and can't stop bouncing!):D)

zuzu xxx

Depression is quite common with metoprolol and all the beta blockers. Astra Zenica admits to an incidence of 5% and of course, since the drug companies always slant side effects in their favor, that 5% probably only counts those people found dangling from trees in the back yard.

zuzu and zip, thank you for the encouragement and information, as well as the laughs. Both were helpful. Zuzu, you might want to check that bouncy thing out...too much broccoli would be my "expert" diagnosis.

I suffered from constant tiredness, apathy, no sex drive and depression for the 6 months I took the beta blocker, Metoprolol, for high blood pressure. I complained to my doc about these symptoms, but he told me they would disappear with time. They didn't. Finally, I just demanded that another drug be tried, and after long trials of nearly all the HBP drugs, I now take a relatively benign ACE-2 inhibitor. While on the beta-blocker, I also developed a first time rash, which is listed as a not so common side effect. What they don't tell you is that beta-blockers can cause psoriasis to develop in people who have never had it before. Now 15 years after taking that blasted drug for only 6 months, I still have psoriasis. What a price to pay! Psoriasis is a horrible disease of the immune response and considered incurable. I wish I had at least been given all the facts before trying the drug. I wish I had done my own research first, and most of all, I wish I had stopped taking it when I obviously felt so poorly on it!

yes, yes, yes! I was put on metropropol and fell into a depression. I call that drug the "med from hell". I got off it! It slowed me down too. I'm too young for that! I got switched to verapamil. I find that since I have been taking my calsium/magnisium my heart rate has slowed down. Thedr that put me on metropropol wouldnt help me with the depression either. I had to see my obgyn to get help. the man is not my dr anymore!!!!!