krupp
03-25-2004, 11:27 AM
My recent levels where
Chol-210
tri-246
I have been on a strict diet plus Tricor for the past few months. Now the Doc has added Lipator. I was on Lipator before but had problems with kidney function readings. He now claims doctors do not feel that is much of a concern as before. So now I am on both. I am not to crazy about this and would like to hear from comments from you folks on this.
Thanks
Kevin
Chol-210
tri-246
I have been on a strict diet plus Tricor for the past few months. Now the Doc has added Lipator. I was on Lipator before but had problems with kidney function readings. He now claims doctors do not feel that is much of a concern as before. So now I am on both. I am not to crazy about this and would like to hear from comments from you folks on this.
Thanks
Kevin
Sponsor
HeyThere
03-25-2004, 10:03 PM
correct me if I am wrong wasn't tricor and another statin now pulled used in combination and caused several deaths. Lipitor is very similar to that pulled statin. I always do _____negative side effects toxic harvard (or berkley or world health organization) give it a go on your searching.
zip2play
03-26-2004, 10:48 AM
Tricor should be used with caution with any statin. Both have their main action in the liver and thus liver irregularites are much more likely when taking both together.
Monitor liver functions well.
Also since both can cause rhabdomyolysis, it's risk will increase proportionately.
I think the Baycol deaths (52 ish) were caused by the Baycol (cerevastatin) itself and didn't really involve fenofibrate so it might be analagous to aspirin and arsenic being a dangerous combination!
I'm not too up on the facts about the Baycol lawsuits, though.
Monitor liver functions well.
Also since both can cause rhabdomyolysis, it's risk will increase proportionately.
I think the Baycol deaths (52 ish) were caused by the Baycol (cerevastatin) itself and didn't really involve fenofibrate so it might be analagous to aspirin and arsenic being a dangerous combination!
I'm not too up on the facts about the Baycol lawsuits, though.
HeyThere
03-26-2004, 10:54 PM
I think the Baycol deaths (52 ish) were caused by the Baycol (cerevastatin) itself and didn't really involve fenofibrate so it might be analagous to aspirin and arsenic being a dangerous combination!
I'm not too up on the facts about the Baycol lawsuits, though.
Well I thought my auxillary brain was right and it is : under google search tricor negative side effects toxic harvard ---first one listed reuters health well connected doc 23----written by medical doctors prof. at harvard----go to the last third of the document under the box combinations ----Baycol cerivastatin given with fibates---fibric acid derivatives fenofibrites---
This is a great document but I can't list the site or quote from it because I would need permission from the author and permission from the moderators here so you can search it yourself it is a wealth of information on this forum.
Baycol is next to lipitor in structure so consider that.
I'm not too up on the facts about the Baycol lawsuits, though.
Well I thought my auxillary brain was right and it is : under google search tricor negative side effects toxic harvard ---first one listed reuters health well connected doc 23----written by medical doctors prof. at harvard----go to the last third of the document under the box combinations ----Baycol cerivastatin given with fibates---fibric acid derivatives fenofibrites---
This is a great document but I can't list the site or quote from it because I would need permission from the author and permission from the moderators here so you can search it yourself it is a wealth of information on this forum.
Baycol is next to lipitor in structure so consider that.
jblondi
03-28-2004, 12:25 PM
I am on both of those drugs now, and have been for a little over 2 years. The lipitor works well with lowering cholesterol, and the tricor has an added kick to the triglicerides. My recent levels chol - 179, tri - 321. My numbers will probably be higher then yours because my condition is heridatary with triglycerides up in the 4000 range prior to meds.
vipergg22
03-28-2004, 10:32 PM
Your doctor is nuts to put you on both , it is even stated in the tricor side effects that is not worth the risk . Below are direct quotes from the tricor literature .
HMG-CoA reductase inhibitors: Rhabdomyolysis has occurred when lovastatin was administered in combined therapy with gemfibrozil, a compound of the fibrate class related to fenofibrate. In most patients who have had an unsatisfactory lipid response to either drug alone, any possible benefit of combined therapy with an HMG-CoA reductase inhibitor and TRICOR is not outweighed by the risks of severe myopathy, rhabdomyolysis, and acute renal failure. There is no assurance that periodic monitoring of creatine kinase will prevent the occurrence of severe myopathy and kidney damage.
HMG-CoA reductase inhibitors: Rhabdomyolysis has occurred when lovastatin was administered in combined therapy with gemfibrozil, a compound of the fibrate class related to fenofibrate. In most patients who have had an unsatisfactory lipid response to either drug alone, any possible benefit of combined therapy with an HMG-CoA reductase inhibitor and TRICOR is not outweighed by the risks of severe myopathy, rhabdomyolysis, and acute renal failure. There is no assurance that periodic monitoring of creatine kinase will prevent the occurrence of severe myopathy and kidney damage.
jblondi
03-28-2004, 11:32 PM
Very good point...I was not aware of the severity of the side effects of these drugs combined. I have a quote from the current lit as well...
"The combined use of TriCor and HMG-CoA reductase inhibitors should be avoided unless the benefit of further alterations in lipid levels is likely to outweigh the increased risk. The combined use of fibric acid derivatives and HMG-CoA reductase inhibitors has been associated with rhabdomyolysis, markedly elevated creatine kinase levels and myoglobinuria, leading to acute renal failure. "
I think for my case with lipids off the chart there was a need, but I now need to be re-evaluated. Thanks.
"The combined use of TriCor and HMG-CoA reductase inhibitors should be avoided unless the benefit of further alterations in lipid levels is likely to outweigh the increased risk. The combined use of fibric acid derivatives and HMG-CoA reductase inhibitors has been associated with rhabdomyolysis, markedly elevated creatine kinase levels and myoglobinuria, leading to acute renal failure. "
I think for my case with lipids off the chart there was a need, but I now need to be re-evaluated. Thanks.