scotsman9
09-24-2004, 09:20 PM
Hi All,
Another interesting article possibly explaining why SSRI treatment may benefit and possibly accelerate inner ear healing.
Treatment with selective serotonin reuptake inhibitors for enhancing wound healing
Alex Malinin, Benjamin Oshrine and Victor Serebruany
Medical Hypotheses 2004
Volume 63 (1):103-9.
These (SSRI) agents are also known to exhibit potent antiplatelet and endothelium protective effects.
Serotonin synergistically enhances fibroblast growth factor-2 (FGF-2)-induced tissue proliferation. Through an active transport process, serotonin rapidly elevates O2 formation, stimulates protein phosphorylation, and enhances smooth muscles cells and fibroblast proliferation.
Animals studies demonstrated that SSRI treatment increases the proliferation of brain neurons. These findings raise the possibility that increased cell proliferation and increased neuronal number may be a mechanism by which SSRI's treatment overcomes stress-induced atrophy, and may contribute to the therapeutic actions of antidepressant treatment. SSRIs may represent an attractive addition to the wound healing process.
Scott :cool:
Another interesting article possibly explaining why SSRI treatment may benefit and possibly accelerate inner ear healing.
Treatment with selective serotonin reuptake inhibitors for enhancing wound healing
Alex Malinin, Benjamin Oshrine and Victor Serebruany
Medical Hypotheses 2004
Volume 63 (1):103-9.
These (SSRI) agents are also known to exhibit potent antiplatelet and endothelium protective effects.
Serotonin synergistically enhances fibroblast growth factor-2 (FGF-2)-induced tissue proliferation. Through an active transport process, serotonin rapidly elevates O2 formation, stimulates protein phosphorylation, and enhances smooth muscles cells and fibroblast proliferation.
Animals studies demonstrated that SSRI treatment increases the proliferation of brain neurons. These findings raise the possibility that increased cell proliferation and increased neuronal number may be a mechanism by which SSRI's treatment overcomes stress-induced atrophy, and may contribute to the therapeutic actions of antidepressant treatment. SSRIs may represent an attractive addition to the wound healing process.
Scott :cool: