<h2> Hey ya'll, I've been taking Nexium for about 4 days now, and I am very tired, I"m wondering if it is a side effect. Have any of you experienced fatigue while being on a PPI?. I started taking Iron and B12 today, hoping to combat it.

Darlene

I'm not sure if the tiredness is from Nexium or more related to the reflux disease itself. I was on 100mg Nexium and VERY tired, but, following surgery I was off PPIs for awhile and the tiredness did not improve at all.