susanp
11-06-2004, 10:12 PM
Could an elevated b-12 have anything to do with liver damage? I got this result back and my b-12 was 2000. I would appreciate any comments. Thankyou
susanp :)
susanp :)
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MTS
12-01-2004, 03:33 AM
Absolutely.
A normal Cyanocobalamin ranges between 250 and 350.
(Physicians claim a concentration smaller than 50 p/mol is abnormal, however this is not accurate as it's just the minimum to prevent pernicious anemia)
The cyanide part of cyanocobalamin might be causing the trouble. Your liver splits the cyanide from the cobalamin and gets rid of it. If it's too much your liver can experience problems cacthing up.
Alllthough it won't do any fatal damage to your liver, I still suggest cutting down on B12 usage. It's not as if taking in excessive amounts is beneficial if, like your bloodwork proves, your body can absorb B12. (People with pernicious anemia - like me - or those having parts of their stomach removed can safely take in extreme amounts of B12 with only about a percent of it being absorbed)
Also, serum B12 is not a realy good indicator of *actual* B12, but in your case it probably is seeing as the numbers are so high there's little room for error. Unless, offcourse, (if you're taking subdermal B12 shots) the nurse or doctor may be accidentally be putting it in your veins.
MTS
A normal Cyanocobalamin ranges between 250 and 350.
(Physicians claim a concentration smaller than 50 p/mol is abnormal, however this is not accurate as it's just the minimum to prevent pernicious anemia)
The cyanide part of cyanocobalamin might be causing the trouble. Your liver splits the cyanide from the cobalamin and gets rid of it. If it's too much your liver can experience problems cacthing up.
Alllthough it won't do any fatal damage to your liver, I still suggest cutting down on B12 usage. It's not as if taking in excessive amounts is beneficial if, like your bloodwork proves, your body can absorb B12. (People with pernicious anemia - like me - or those having parts of their stomach removed can safely take in extreme amounts of B12 with only about a percent of it being absorbed)
Also, serum B12 is not a realy good indicator of *actual* B12, but in your case it probably is seeing as the numbers are so high there's little room for error. Unless, offcourse, (if you're taking subdermal B12 shots) the nurse or doctor may be accidentally be putting it in your veins.
MTS
susanp
12-01-2004, 01:57 PM
Thankyou For Your Reply:
I didnt think I was going to hear from anyone since this is rare. Reading your reply was very interesting. You seem to know more about it than my doctor does. I ask him to explain why that could happen and he didnt have much to say.
susanp :)
I didnt think I was going to hear from anyone since this is rare. Reading your reply was very interesting. You seem to know more about it than my doctor does. I ask him to explain why that could happen and he didnt have much to say.
susanp :)
turl
01-30-2005, 11:06 PM
Maybe you have a "transport" problem somewhere in the B12 cycle--where the cyanocobalamin fails in getting converted into the 2 usable types: methylcobalamin (used in the brain and nerves) and adenosylcobalamin (aka Dibencozide, which is used by cells in the energy production cycle).
susanp
01-30-2005, 11:57 PM
You could be right. As I said before,some of you folks seem to know more than my gp does. I have since been diagnosed with sjogren's autoammune disease ,and have no energy.
susanp :)
susanp :)