Have any of you been on estriol(E3) alone for your symptoms? It is not usually prescribed by most doctors. I've been on and off HRT for the last 7 years, usually going off due to hypersensitivity and tenderness in my breasts. I've read on a few sites that estriol is the least stimulating to breast tissue, yet all of the doctors I've talked to insist that estadiol(E2) is the least stimulating to breast tissue. I want to ask my current doctor to prescribe estriol cream for me, but was hoping to get some feedback here first. Any info is appreciated.