I have had several skin cancers removed by surgery. My doctor now has me do a treatment with Efudex every second year. This greatly lessons the number of lesions to be frozen, and has lessened the surgical to only one cancer in three years. To answer your question, yes there is som pain. For me it is so slight that I would trade it any time to getting these lesions frozen off. It does turn my arms and face an ugly mottled red. This only lasts for ten days to two weeks. I hope that both of you are doing everything that you can to avoid futher exposure to the sun.