I don't know for a fact, but since the skin is the body's largest organ, and very porous, and since bleach is a chemical...why not? I'm sure the Sally Hansen company has tested it thoroughly, just like shampoo and hair dye, but..... I myself worry about hair dye causing cancer. But where are the statistics? I think I'll search around, and post again if I find anything about dye or bleach. :)