If anyone could help me out with advice I would love it I am at my end, has anyone had sucess on this combo after other ad's have failed. I started using Zoloft 25mg years ago for sad and depression. It made me feel wonderful life was enjoyable, not mania but my life is good so I could just enjoy it and the people around me. I took it for many years but started to abuse it meaning I would only take it once every 3 days or so. Then when I started using it religiously at 100mg and it wasnt working anymore. Dr. put me on 200mg a day for 2 more weeks and that didnt work. I switched to paxil immediately went to 40mg a day no side effects except the obvious sexual and insomnia for about 1 week. I took that med for 6 weeks with no results whatsoever. So I sugessted to my dr to augment the paxil with wellbutrin I was on the paxil with wellbutrin for 2 weeks and felt nothing still. So I recommened to my dr. to put me on effexor and wellbutrin even though after 5 weeks on wellbutrin I have felt nothing whatsoever. Supposedly its is only a minor inhibitor of dopamine and norepineperine so I concluded that effexor would boost the serotonin if I have any left as well as the nor and the wellbutrin would add benefits of the dopamine. Im on 300mg a day of well Sr and 150mg a day of effexor xr. Its been 8 days and I dont feel jack, im loosing hope that anymed will ever help me again and then my only hope is ECT or then just call it quits. Has anyone had luck with medication resistant depression and using wellbutrin and effexor or any other combos after failed trials with other drugs. Thanks in advance.

Hi Johnny;

I've tried 4 different meds, Lexapro, Celexa, Remeron, and Wellbutrin and I don't believe any of them have done a thing. My dr. tried varying dosages and even combinations. I'm told that meds help about 2/3s of people but they havent me and it may be that you are in the same category. Honestly, I'm sick and tired of feeling lifeless and can relate to your frustration with the ineffectiveness of the meds. I so badly wish I could enjoy life again as I have a lot to be thankful for, but so far no luck. I'm thinking of checking myself into a Zen center or clinic of some sort to see if that does any good.
I wish you the best of luck and wish I had a suggestion other than the ones that everyone says help. i.e. exercise, diet etc. I've literally combed the internet and can't find a solution. The "change your way of thinking" approach is great in concept, but tough to execute. I've tried. I'm hoping that time will help as will a change in my environment.

I just started the effexor xr 150 mg doc put me on 75 but I needed immediate relief I had lost so much hope and its working I feel good now yet it fails to do anything yet for my social anxiety its only been 11 days so hopefully that effects comes on with time or an increase of the dosage thans for the reply