ManonB
04-26-2001, 04:10 PM
I am 21 wks pregnant, and have just found out that our expected son has a translocation
of chromosomes 5 & 16. This translocation is apparently balanced (nothing appears to have been lost or gained in the process) however, we are aware that there are some risks which exist due to the actual chromosome breakage. The breakpoints are as follows 5:q23 and 16:q24. We are also aware that our son may have some reproductive issues later in life, but aren't worrying about those just yet. Does anyone know more about this type of thing, or can anyone point me in the right direction as to what to expect? Thanks,
Manon
of chromosomes 5 & 16. This translocation is apparently balanced (nothing appears to have been lost or gained in the process) however, we are aware that there are some risks which exist due to the actual chromosome breakage. The breakpoints are as follows 5:q23 and 16:q24. We are also aware that our son may have some reproductive issues later in life, but aren't worrying about those just yet. Does anyone know more about this type of thing, or can anyone point me in the right direction as to what to expect? Thanks,
Manon
Sponsor
eweejoe
04-26-2001, 09:59 PM
http://www.wcox.com.au/transloc.htm
"a reciprocal translocation does not result in a loss of genetic information; therefore individuals can be viable and normal"
"Balanced reciprocal translocation is unlikely to have any severe consequence for the cell because, even if one of the breakpoints lies within a gene, most mutations are recessive. Translocations can however give rise to difficulties with reproduction."
I had never heard of this until your post and went and did some research. I hope these sites and posts help you. From what I can tell, the effects on the baby are only if the translocation is unbalanced. And like you mentioned, there can be issues for him in the future if he decides to have children, but that isn't a definate and who knows where genetic science will be 25 years from now? :)
Good Luck to you guys and your impending little guy! God Bless.
"a reciprocal translocation does not result in a loss of genetic information; therefore individuals can be viable and normal"
"Balanced reciprocal translocation is unlikely to have any severe consequence for the cell because, even if one of the breakpoints lies within a gene, most mutations are recessive. Translocations can however give rise to difficulties with reproduction."
I had never heard of this until your post and went and did some research. I hope these sites and posts help you. From what I can tell, the effects on the baby are only if the translocation is unbalanced. And like you mentioned, there can be issues for him in the future if he decides to have children, but that isn't a definate and who knows where genetic science will be 25 years from now? :)
Good Luck to you guys and your impending little guy! God Bless.
ManonB
04-28-2001, 03:57 PM
Eweejoe, Thank You for the valuable and reassuring information. I didn't know how else to reach you so I posted here...I went to the site you referred me to, and printed out some more info to take with me to the doctor's this week. Again thanks for your time & effort, God Bless,
Claude and Manon, and little Matthieu
Claude and Manon, and little Matthieu