Yes, as a matter of fact, I have experienced that. Not only that, but I didn't get my first period back til 5 years after stopping Depo. I also was diagnosed with PCOS. The doctor that diagnosed my PCOS (from Mayo Clinic) told me that he is seeing more and more cases of PCOS in women after they use Depo. He said what is making him believe that Depo is the culprit is because many of the women he sees never had any of the symptoms of PCOS whatsoever prior to using Depo. I for example, never missed a single period prior to using Depo, and I had 2 pregnancys that came about with no effort. Since Depo, it took me 2 years to conceive. I was on Clomid for 4 months (which is the only months in the first 5 years after Depo that I had a period....like I said, my first real non-induced period came 5 years after Depo). I have hair growing everywhere, gained weight and am also a diabetic now. So, for me.......I think Depo was a bad choice, one that I have to live with for the rest of my life......and the culprit. Many people will say that their experience with Depo was great, but for the rest of us...........our stories are all very similar.