Jenny, I know how you feel. I am on Avonex and it hasn't really sunk in yet. It will be a year in October that I've been injecting myself. Every Sat night, it still doesn't seem real. I guess until they come up with something else, it is something we have to accept. My shots must be working though because I just had a follow up MRI and it showed remarked improvement. I guess the lesions are looking "better" (?). I'll know better when I have my appt in Dec. But if the shots are slowing down the progression even a little bit, it is worth it. As far as hurting, my intramuscular shot doesn't hurt much. It did the one time and I think my muscle was tensed. It gives me a sense of control though, to give myself the shot. We are taking action against this stupid disease, remember that! Good luck. Let us know how it goes.