catnap
01-04-2006, 01:14 PM
Re: Is there a difference: Methadose and Methadone
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Methadose is Mallinkrodts crappy generic, Roxanne is also generic for name brand Dolophine. I took meth for 2&1/2 years and the two time I was given methadose at the pharmacy it caused withdrawal.
My brother was the Quality control and FDA liason for another International pharma maufacturer and I sent 1 10mg tablet to him and he tested the amount of methadone HCL in a 10 mg Meth Tab, It came back at 8.3, 17% less than what is supposed to be in it but that still falls within the FDA guidelines for generic equivelance. If you start and stick with it because you can't find roxanne, you won't know what your missing, but if you start with Roxanne, don't give the mallincrap a try.
This is the article that explains what equivalent actually means and how important it is to be truly equivalent. It discuses how the generics must fall within ranges that are expectable parameters that don't create a large enough change to be clinically significant in the FDA's mind.
http://www.americanheart.org/presenter.jhtml?identifier=3015266
Approval of a generic version of a proprietary drug by the FDA requires demonstration of “chemical equivalence” (similar quantities and availability of the active ingredient in proprietary and generic formulations), and “bioequivalence” (defined by absorption parameters generally falling between 80% and 125% of those obtained with the proprietary agent under the same testing conditions) (2) The use of the –20%/+25% rule is based on a regulatory decision that for most drugs that difference in concentration of the active ingredient in blood will not be clinically significant.
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There are parameters for generic testing against the proprietary drug "name brand". The scary thing is, there are no clinical testing or comparison from one generic to the other, just comparison to the proprietary drug. So if one generic company is at the top of the parameter and using +25% and the other is at the bottom using -20% then your talking about a 45% variation.
Only 17% of the polled docs knew what the parameters where to obtain bio equivelance. Pharmacist are no better and they are paid a bonus to push generics due to the GPM.
It's not that all generics are inferior, you just never know when you move from one manufacturer to another. Stick with one and don't make exceptions when it comes to meth and some other meds out there. JMO.
Take care, Dave
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Last edited by Shoreline : 10-24-2005 at 01:32 PM.
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Methadose is Mallinkrodts crappy generic, Roxanne is also generic for name brand Dolophine. I took meth for 2&1/2 years and the two time I was given methadose at the pharmacy it caused withdrawal.
My brother was the Quality control and FDA liason for another International pharma maufacturer and I sent 1 10mg tablet to him and he tested the amount of methadone HCL in a 10 mg Meth Tab, It came back at 8.3, 17% less than what is supposed to be in it but that still falls within the FDA guidelines for generic equivelance. If you start and stick with it because you can't find roxanne, you won't know what your missing, but if you start with Roxanne, don't give the mallincrap a try.
This is the article that explains what equivalent actually means and how important it is to be truly equivalent. It discuses how the generics must fall within ranges that are expectable parameters that don't create a large enough change to be clinically significant in the FDA's mind.
http://www.americanheart.org/presenter.jhtml?identifier=3015266
Approval of a generic version of a proprietary drug by the FDA requires demonstration of “chemical equivalence” (similar quantities and availability of the active ingredient in proprietary and generic formulations), and “bioequivalence” (defined by absorption parameters generally falling between 80% and 125% of those obtained with the proprietary agent under the same testing conditions) (2) The use of the –20%/+25% rule is based on a regulatory decision that for most drugs that difference in concentration of the active ingredient in blood will not be clinically significant.
........................................ ...........................
There are parameters for generic testing against the proprietary drug "name brand". The scary thing is, there are no clinical testing or comparison from one generic to the other, just comparison to the proprietary drug. So if one generic company is at the top of the parameter and using +25% and the other is at the bottom using -20% then your talking about a 45% variation.
Only 17% of the polled docs knew what the parameters where to obtain bio equivelance. Pharmacist are no better and they are paid a bonus to push generics due to the GPM.
It's not that all generics are inferior, you just never know when you move from one manufacturer to another. Stick with one and don't make exceptions when it comes to meth and some other meds out there. JMO.
Take care, Dave
------------
Last edited by Shoreline : 10-24-2005 at 01:32 PM.
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01-04-2006, 01:48 PM
Hey Tina: I hope you check this thread and get this post. I'm glad you found the info you wanted with Catnap's help. I thought of the same thing late last night. Not sure why I didn't yesterday afternoon when we were posting back and forth. Oh well, you found out what I was telling you about, that's the important thing. What's the decision? You going with Methacrap or Methadone?
tina76
01-04-2006, 02:14 PM
Thanks for finding this for me! That is great. I'm printing it out right now. It still baffles me that they can do this!!!! Yikes.
Well I am NOT planning on using the methadose at all. I called the pharmacy yesterday and while the pharmacist (and yes she was the actual pharmacist) was irritated by my questioning her, she did say that she had enough of the good stuff to fill my script of 120 on Thursday and if not, she would order some more. Of course, she did not "need" to take down my name or anything so who knows if she will follow thru or not. I'm planning on calling them on Wednesday to make sure that they have it for sure. That way, if they don't I can still do some calling around to other pharmacies in my town and then let my PM doc know durning my appt that Thurs morning that I will need to change the pharmacy on my methadone contract. Hopefully they will just have it and everything will work out just fine. Even if the do, I guess it will just have to be routine for me to call them every month and make sure they have it in stock for me.
All I have left out of my half/half prescription is the Methadose for the next week. So it will be interesting to see if I notice the difference. Last week I just called them and told them that the 30mg didn't seem to be cutting it for me consistently and they upped my dosage to 40mg. Now I'm wondering if on the days that it didn't feel as effective if I was taking the Methadose that day... Interesting. I guess I'll know in the next couple of days if it's going to make a difference. At least it's only a week. I go in next Thrusday at 10:30am.
I'm so glad I have all you guys to give me this information! I would be totally in the dark about everything if it wasn't for this board!!!
Well I am NOT planning on using the methadose at all. I called the pharmacy yesterday and while the pharmacist (and yes she was the actual pharmacist) was irritated by my questioning her, she did say that she had enough of the good stuff to fill my script of 120 on Thursday and if not, she would order some more. Of course, she did not "need" to take down my name or anything so who knows if she will follow thru or not. I'm planning on calling them on Wednesday to make sure that they have it for sure. That way, if they don't I can still do some calling around to other pharmacies in my town and then let my PM doc know durning my appt that Thurs morning that I will need to change the pharmacy on my methadone contract. Hopefully they will just have it and everything will work out just fine. Even if the do, I guess it will just have to be routine for me to call them every month and make sure they have it in stock for me.
All I have left out of my half/half prescription is the Methadose for the next week. So it will be interesting to see if I notice the difference. Last week I just called them and told them that the 30mg didn't seem to be cutting it for me consistently and they upped my dosage to 40mg. Now I'm wondering if on the days that it didn't feel as effective if I was taking the Methadose that day... Interesting. I guess I'll know in the next couple of days if it's going to make a difference. At least it's only a week. I go in next Thrusday at 10:30am.
I'm so glad I have all you guys to give me this information! I would be totally in the dark about everything if it wasn't for this board!!!