Hi Guys:

I don't usually post in here but thought you might have some advice for me. My wife recently went on Wellbutrin for her depression. She's tried other stuff in the past (Prozac and Lexapro I think) but said they didn't work. She was actually off meds all together for about 2-3 yrs before getting on the Wellbutrin.

I'm no expert but I think the cure is worse than the disease in this situation. She cries all the time for seemingly no reason. Anytime she has contact with her friends, she comes home crying her eyes out because they all seem so happy and she feels so sad and alone.

When she wasn't on any medication, she'd have the occasional bad-day / breakdown. But now she has that kind of thing 5 times a week. I could handle a few times a year, but I'm at my wits end dealing with her day after day after day.

Is this a temporary thing? Or should she try another type of medicine? Can anybody relate to this? Thanks for the help and advice.

Boy, can I relate to your wife. I was put on wellbutrin for a couple of months, and it made me so emotional, so spastic, so crazy!! My doc took me off when I told him I couldn't handle the emotion overflow. Some people say Wellbutrin works wonders for them, but for some of us it only deepens our depression. I would advise your wife to talk to her doctor. They usually say give it 4-6 wks, but if she is really down, they may let her off early. I've been on tons of antidepressants since I was 19 (now 27) and what worked best for me was celexa- I had no side effects at all.... Don't know if I helped or not, but thought you should know there are others out there who did NOT improve with Wellbutrin.

I was on Wellbutrin XL and didn't like it. It made me so emotional, I cried at the drop of a hat and it also made me very short-tempered. The only good thing was that it gave me energy. I have weaned off it and finally feel more stable. I do have OCD issues and will start Luvox for that so I'm hoping it goes well.

I think your wife should talk with her dr. about switching. Poor thing - there has to be something to help her.

First of all, what has happened with your wife sounds exactly like what happened to me. However, I stuck with it and was about to quit when I started feeling better. Now I feel great most of the time. But right after starting it I was MORE depressed for about four months.

There is another med that I was on that worked very well also. I had to stop taking it because it is too expensive and I have a very large deductible on my health insurance. It's called Abilify and in the past has been used for psychotic conditions but has recently been approved for depression. It worked for me right away.

Hope your wife finds something that works. You just have to keep trying.

Thanks for all the advice and support. It sounds like it takes a while for the medicine to be effective. I just hope I can tough it out. It's so hard when she gets like this.

And I suspect her mood might be changing...and getting worse. Last night she was so angry and mean to me. I almost wanted to leave the house rather than put up with her attitude. It's really putting such a strain on things.