My husband is taking Zoloft 150mg/day. It isn't helping AT ALL. The depression killed his libido, and the Zoloft doesn't help with that either. Can anyone recommend an anti-depressant that doesn't have sexual side effects that might actually work? He has tried Paxil and Elavil in the past, the Paxil worked but destroyed the libido, so he stopped taking it, but it never really got back to normal after that.

Wellbutrin is known for it's lack of effect on the libido. You might want to try and ask his doctor about that.
Meg

Hi there!
Well, I agree with the individual that replied previously to me with the possibility of one of the versions of Wellbutrin(Wellbutrin, Wellbutrin SR, Wellbutrin XL) being an option for you husband. It does definitely have a reputation (and the stats to back it, I think) of being more friendly to one's sex life. There are two other drugs that come to mind as well. One is Serzone. It has a reputation for causing less sexual dysfunction. Plus there is Remeron (I think that is the way it is spelled.) The Serzone, I think, has to be carefully monitored because of potential risks to the liver. The Remeron, I think tends to cause weight gain, and ummm.....what was the other side effect now.....ummm...I think maybe sedation. Anyway those are a couple of options to explore. F.Y.I. You responed to a post that I put up the other day. I too am taking Zoloft, as you know. I am very reluctant to give it up because it has been quite effective for me, but just has that sexual side effect drawback for me. So, perhaps your husband would benefit with staying on the Zoloft and adding the Wellbutrin. It did not do anything for my sexual dysfunction, but it has for a lot of other people. So, it may be very well worth the effort to bring the idea up with your husband's doctor. Then of course there is trying the BuSpar, Ginko Biloba, Amantadine, Yohimibe, etc. Good luck and let us know how things turned out.

yes the sexual side effects SUCK...but be patient with him if he doesn't want sex, if you aren't you'll only add to his woes....hopefully the ad's aren't a permanent thing...maybe he just need a few months of them.... and then things will be back to normal