Does anyone feel like their medication makes them feel worse? With every medication I have tried, there was always a negative effect. Right now, I feel horribly restless and anxious and have been feeling that way ever since I started taking medication again.

It's hard now to take my meds on a day-to-day basis. I feel sick looking at them, because I know they are making my depression worse. I'm depressed with a lot of energy, and that's a bad thing for me.

What keeps you motivated to take your medication? I feel like I have none since they don't seem to work, but I do have to listen to the pdoc and try not skip days or mess with them.

Another thing, often with medications I feel "out of my body" and I won't remember most of the things I did during the day. Has anyone felt this before? I also feel out of touch with reality...hard to describe.

My husband was just diagnosed bipolar and is starting to take Seroquel. He has done nothing but sleep since he started taking it(May23). He says he doesn't like the way he feels on it and is very agitated and irritable. Snaps at everyone for nothing. I read it blocks dopamine and serotonine. I told him he seems very "Zombie" like now. I have sat there and watched him while he is 'sleeping' and he jerks, talks and his eyes (while closed) dart around. Scares me to see him like that. He always was a calm sleeper with occasional "restless legs". Anyway, I am concerned about the way this medicine is making him, so I am curious too if anyone else is having this much trouble with taking them. He is not sure the new problems are worth it.