I've been taking aciphex twice a day (am and 5 pm) for months now and have found it to work great. I had to switch ENT's recently because I had an insurance change, and he now has me taking 300 mg of zantac before I go to sleep. Plus on top of that my GP put me on an antibiotic for a UTI. My reflux is out of control now. I quit taking both the zantac and the antibiotic to figure out which is causing it. Here's my question........ does anyone else take 2 ppi's and zantac on top of that? What times of day to you take the pills. I had hoped to never feel like this again. Its back to the drawing board for me. Thanks, Lori

Ive been at the drawing board for ahwile now lol..Ive bounced around on PPI's now back on Aciphex 20 mg in the a,m.Than 20 mg at night.I here Zantac works great for nightime heartburn.Mine has a mind of its own,and meds arent working to great no trigger etc..Just have to mess with it a bit,or maybe just let time pass,and they will start working again..

Just curious, and it may seem like a strange question, but have all of you who take 2 ppi a day been diagnosed with lpr, and did the Dr prescribe them? My endo and I thought he was good, never even mentioned that it could be this.

I was prescribed 2 PPI's/day supposedly for an ulcer or gastritis. The endoscopy showed neither after 5 months of taking these. I think I'll begin decreasing the pills, I can't stand the night mares.