FYI there have been several posters that say there is a difference between the two according to the FDA:

Who should take prescription strength Prilosec rather than Prilosec OTC?

Although the two products contain omeprazole, prescription Prilosec is for treating conditions such as inflammation of the esophagus (esophagitis), ulcers, and other medical conditions for which a doctor’s supervision is needed.

For this reason, stop taking Prilosec OTC and tell your doctor if you:

* are not feeling better and your heartburn continues to worsen
* need to take this product for more than 14 days

* need to take more than 1 course of treatment every 4 months

Prilosec OTC is not appropriate for adults who:

* have only occasional heartburn
* have one episode of heartburn a week or less
* want immediate relief of heartburn

Just thought this might help some out there. I, for one , never believed there was a difference, but aparently there is.

Prilosec OTC is a name that is licensed from Astrazeneca, but the drug is not produced by Astrazeneca. Only prescription Prilosec is produced by Astrazeneca.

My ENT has stopped recommending Prilosec OTC to her patients because it simply fails most patients with chronic reflux.

My personal experience from switching briefly from Nexium to Prilosec OTC (2 months) confirms this.