wife is on rebif everthing seemed ok till sunday when diarrea set in with stomach cramps. anyone heard of such a thing while taking rebif? shes been on it for about 2-3 weeks. she took over the counter for the diarrea but not working. just keeps pooping.(sorry)
any thoughts would be greatly apprecaited!:(

Hey Wallaye.
Has your wife increased the amount? I am on Rebif...when I started, the first 2 weeks were 7mcg...then, the box tritrated to 22 mcg...then it went to 44 mcg.
Its possible that you and she didnt even know that the sryinges were a titration. If this is the case, then the increase in mcg would account for her all the sudden having diarhea as well as cramps and flu like symtoms. I didnt start having reactions until the end of the first package of Rebif....those side effects can last as long as 3-4 months...they should ONLY happen 2-8 hours after the shot, and go away in between shots...

Is she taking Aleve or any over the counter pain med 1/2 hour before the shot? She should be. I like Aleve because you only take one pill and it lasts 12 hours...you basically can get a good nights sleep!

If the problems continue, she should call her neuro and talk to him or his nurse...but check out the box, see if it says titration pack on it...and even if it doesnt, she hasnt been on the meds that long...its very possible that the side effects are STARTING to kick in and this will pass...

hope this helps.
Nikki

msnik thank you first of all. wifes been waiting all day for ms lifelines nurse to call.
this was 2nd dose of 22mcg 1st one was friday and then sun. friday she was ok, but after work her whole body hurt taht could have been related to carring a 20-40 lb bus tub full of dishes. saturday aches and pains and major fatique, aches and pains back on sun then sun night the runs like all the time. yes box states titration.
shes also taking i believe pregnizone and ibprofin per pcp request. shes placing a call tomorrow to nuero, cause this is on and off since sunday night and its almost uncontrolable.
yes it does help! THANK YOU;)

Glad I was able to help! Have your wife ask the Neuro if she can TRY Aleve, which is Naproxen instead of Ibuprofin....its the same type of Non-steroid Anti-inflammatory, but a different chemical makeup...and honestly, ask anyone who Ive recommended this to on this board (do a search on ALEVE here on healthboards) youll see that because it lasts twice as long, people are raving about it....
Of course, get the docs okay first...but its over the counter, found in any drug or grocery store, and costs the same as tylenol! Its not unusual that at this point, she is experincing side effects. I can remember laying on the floor crying I felt so bad 3 hours after my shot....however, dont let her give up! They say it takes 6 months for this Rebif to reach full strength in the body...and it only takes half that time for the body to get used to it and stop having symtoms altogehter! I just celebrated a year on Rebif, and I had NO NEW LESIONS or anything bad on my MRIs last week! Things are looking up for me, overall....rebif is a great drug, you just have to stick out the first few months!
Good luck to her, tell her Im with her, and she has my sympathies because it isnt easy for the body to adjust to it...but its worth it!
Hugs to you both.
N

no news on the runs front. nuero never called back after 3 calls and no call back from ms life lines nurse. i dont get it it seems kind of urgent and with no call back it almost seens if doctor does not feel this is urgent. whats with that? crazy:confused:

Hey there Walleye,
Its true, I'm with Nikki on the Aleve tablets, I positive if it wasn't for Nikki recommending Naprosyn 750 as its called here ( same thing ) i wouldn't be doing my shots.. I hated the side effect my meds had on me. Finally my side effects have gone only when i use Naprosyn. And i did the test , if i stopped using them to take Brufen instead, I'd be sick...Except here i needed a Dr prescription. Hope yr wife starts feeling better soon.

:confused: UPDATE:
Talked to nuero late this after noon he feels and does not believe its related to rebif, his opionion was to stop taking rebif for one week and see what happens. well the wife held of till late last night to take shot, she was feeling somewhat ok the runs stoped. now after she took her shot it seemed to have comeback and now shes wore out like major fatique every muscle hurts. so maybe she caught a bug or something. will try what nuero suggested. also she can not take alieve due to it aggrivating her astma.
(i cant beleive it took nuero almost 36 to have a nurse call back to talk and make a suggestion.) in the docters opionion he stated that rebif does not cause anything like this what so ever. it only causes flu like symptoms.:confused: :confused: