Hi GuyAz I don,t know a whole lot about ipraflavone, but I did do a little reseach(google) on it. From what I remember reading, there was a study done on 128 women taking it, 29 developed a significant drop in there white blood cell counts. Also they were not able to get there lymphocytes back to normal for up to two years. I think it is recommended that for anyone taking it(especially women) that their doctor keep a check on there white blood cell count. I thought this was too risky, as our white blood cells have to do with our immune system, and fighting infections etc. Hope this is somewhat helpful to you.